|Dr Diego Correa
Profesor Asistente, University of Miami, School of Medicine:
Diego Correa, M.D., M.Sc., Ph.D.
(617) 599-8322 (mobile); (305) 243-2228 (work) - USA
firstname.lastname@example.org email@example.com firstname.lastname@example.org M.D. with engineering (Biomedical Engineering – M.Sc.) and basic science (Cellular & Molecular Physiology – Ph.D.) training, offering over 15 years of basic and translational research experience in the areas of adult Stem Cell Biology and Regenerative Medicine, with emphasis on:
- Adult Mesenchymal Stem Cell (MSC) Biology and Stem Cell-based Therapy
- Tissue Engineering (tissue injury and repair)
- Molecular Orthopaedics & Orthobiologics
- Adult Stem Cells in Islet transplantation for type 1 Diabetes Mellitus therapy International consultant, lecturer and instructor in the areas of Regenerative Medicine and Adult Stem Cell Biology/Therapy:
Date and place of birth: 5/1/1973 - Bogotá (Colombia)
Migratory status: Permanent resident (January 2013) CURRENT ACADEMIC POSITION:
Assistant Professor (Research):
Dept. of Orthopaedics (Division of Sports Medicine)
Diabetes Research Institute (DRI) & Cell Transplant Center
University of Miami, Miller School of Medicine
1450 NW 10th Ave, Room 3014 Miami, FL 33136
- Adjunct Assistant Professor:
Dept. of Biology, Skeletal Research Center.
Case Western Reserve University, Cleveland, OH COMMERCIAL / INDUSTRY-RELATED ACTIVITIES:
1. Founder & Owner: Lumos Biomed Consulting, LLC: Medical & Scientific consulting in the areas of Regenerative Medicine, Stem Cell Biology/Therapies and Biotechnology; USA; 2016 - present
2. Shareholder & Strategic Scientific Consultant: Institute for Tissue Regeneration (Colombia); 2011 - present.
Private company (acquired by Procaps SA group), specialized on the generation of Regenerative Medicine-based products such as the autologous regenerative biomembrane - Cytogel®.
3. Scientific Advisory Boards (SAB) / Scientific Advisor:
- Society for Worldwide Medical Exchange, USA, 2016 - present
- Top Health Regenerative Medicine, Mexico, 2016 – present.
- Regenerative Medicine LLC, USA, 2015 - present
- Procaps SA, Cellular Medicine, Colombia, 2014-present.
- GID Americas, Nicaragua, 2013-2015.
- Stem, Medicina Regenerativa, SA, Colombia, 2013-2014.
4. Scientific evaluation of adult stem cell-based companies for capital investment.
- Institute for Tissue Regeneration (IRT): Bogota, Colombia, (2011)
- Cordgenics LLC: Huntington, WV- USA (2013) TRAINING AND EDUCATION:
Postdoctoral fellow / Sr. Research Associate:
Case Western Reserve University, Cleveland, OH (USA); Department of Biology, Skeletal Research Center,
Arnold I. Caplan, PhD Laboratory: June 2009 – June 2010 (Post-doc); July 2010 - August 2015 (Sr. Research Associate). Doctor of Philosophy (Ph.D.):
Yale University School of Medicine, New Haven, CT (USA)
Department of Cellular and Molecular Physiology; Roland Baron, PhD Laboratory. Aug 11th 2004 – Dec 31st, 2007.
Recipient of the George Robert Pfeiffer Fellowship from the Gustavus and Louise Pfeiffer Research Foundation.
Harvard University Medical School - School of Dental Medicine, Boston, MA (USA)
Department of Oral Medicine, Infection and Immunity (Dr. Baron moved to Harvard); Jan 1st, 2008 – May 27th, 2009 Residency in Orthopaedic Surgery:
Fundación Santa Fe de Bogotá - Universidad del Rosario, Bogotá (Colombia)
June 2003 – May 2004 (stopped for PhD application) Master in Science (M.Sc.) in Mechanical Engineering (BME):
Universidad de Los Andes, Bogotá (Colombia).
Biomedical Engineering Group. June 1st 2000 – June 1st 2003. Engineering school full time scholarship. Medical Doctor (MD):
Pontificia Universidad Javeriana, Bogotá (Colombia).
June 1st 1992 – June 1st 1998 LANGUAGES: Spanish (Native);
English (Full professional proficiency);
French (Limited professional proficiency) WORK EXPERIENCE:
1. Correa D, Caplan AI: Bone Marrow Pericytes/MSC: Gatekeepers Controlling Skeletal Metastasis from Melanoma. Provisional patent submitted (2012-2138).
2. Correa D, Caplan AI: In vivo platform for the identification of controling elements during the process of metastatic cancer dissemination to target organs. In review/submission.
3. Ricordi C, García-Contreras M, Correa D, Tomei A: Co-Transplantation of Encapsulated Cell Types within Scaffolds for Cellular Therapies for Combined Intra- and Peri-Capsule Biologic Effect. In review/submission. RESEARCH SUPPORT: Active:
1. University of Miami, Department of Orthopaedics Faculty startup package
Role: PI $300,000 09/01/2015 - 08/31/2018
2. DRI Foundation
Co-transplantation of islet cells with MSC/Exosomes in a novel biological scaffold
Role: Co-PI (Dr. C. Ricordi) $225,927 07/01/2016 – 06/30/2017
Bone marrow MSCs/pericytes: Gatekeepers Controlling Skeletal Metastasis.
Role: Co-Investigator Caplan AI (PI) 08/22/2012 – 07/01/2017
NIH-NCI – RO1 $207,500
Multimodal evaluation of engineered cartilage
Role: Co-investigator Caplan AI (PI) 08/01/2014 – 07/31/2016
NIH-NIBIB – RO1 $250,000
MSCs as probes: Non-destructive evaluation of cellular differentiation during in vitro chondrogenesis.
Role: PI (TR&D 2) Caplan AI (PI) 06/01/2016 – 05/31/2021
NIH-NIBIB – P41 PUBLICATIONS:
1. Carstens MH, Gomez A, Cortes R, Turner E, Perez C, Ocon M, Correa D: “Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells” (in press Stem Cell Research).
2. Correa D, Lietman SA (2016), “Articular Cartilage repair: current needs, methods and research directions”, (in press Seminars in Cell & Developmental Biology).
3. Correa D (2016), “Mesenchymal Stem Cells in tumor formation and dissemination” Current Stem Cell Reports 2: 174-182.
4. Correa D, Gomez A, Vargas C, Turner E, Carstens MH (2016): “Adipose-derived stromal vascular fraction (SVF) for the treatment of Osteoarthritis of the knee, functional outcome and anatomic recovery of the cartilage: a case report”; CellR4 Journal, 4 (1): e1768.
5. Somoza RA, Correa D, Caplan AI (2016): “Roles of Mesenchymal Stem Cells as Medicinal Signaling Cells”; Nature Protocols, 11 (1).
6. Carstens MH, Correa D, Gomez A, Turner E, Valladares S (2016): “Subcutaneous reconstruction of hand dorsum and fingers for late sequelae of burn scars using adipose-derived stromal vascular fraction (SVF)”; CellR4 Journal, 3 (5): e1675.
7. Correa D, Somoza R, Lin P, Schiemann WP, Caplan AI (2016): “Mesenchymal Stem Cells regulate melanoma cancer cell extravasation to bone and liver at their perivascular niche” Int. J. Cancer; 138 (2): 417-427.
8. Correa D, Somoza RA, Greenberg SA, Lin P, Rom E, Welter J, Duesler L, Yayon A, Caplan AI (2015): “Sequential stimulation with Fibroblast growth factors (FGFs) 2, 9 and 18 regulate the ultimate phenotype of MSC-derived chondrocytes”, Osteoarthritis and Cartilage, 23 (3): 443-453.
9. Somoza R, Welter JF, Correa D. Caplan AI (2014): “Chondrogenic differentiation of Mesenchymal Stem Cells: unfulfilled expectations and new challenges”, Tissue Engineering Part B, 20 (6): 596-608.
10. Lin P, Correa D, Caplan AI (2014): “Serial transplantation and long term engraftment of intra-arterially delivered clonally derived Mesenchymal Stem Cells to injured bone marrow”, Molecular Therapy, 22 (1): 160-168.
11. Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R (2013): “Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages”, Journal of Experimental Medicine, 210 (5): 969-985.
12. Lin P, Lin Y, Lennon D, Correa D, Schluchter M, Caplan AI (2012): “Efficient lentiviral transduction of human mesenchymal stem cells (hMSCs) that preserves proliferation and differentiation capabilities”, Stem Cell and Translational Medicine 1: 886-897.
13. Correa D, Segal SS (2012): “Neurovascular Proximity in the Diaphragm Muscle of Adult Mice”, Microcirculation, 19(4): 306-315.
14. Lin P, Correa D, Lin Y, Caplan AI (2011): “Polybrene Inhibits Human Mesenchymal Stem Cells Proliferation during Lentiviral Transduction”, PLoS One, 6 (8): e23891.
15. Caplan AI, Correa D (2011): “MSC: An Injury Drugstore”, Cell Stem Cell, July 8; 9 (1): 11-15.
16. Caplan AI, Correa D (2011): “PDGF in Bone Formation and Regeneration: New Insights into a Novel Mechanism Involving MSCs”, Journal of Orthopaedic Research, Dec 2011; 29 (12): 1795-1803.
17. Correa D. and Goldberg VM (2011): “Stem Cells in Orthopaedics”, American Academy of Orthopaedic Surgery (AAOS) News; July 2011; 5 (7): 41-45.
18. Seriwatanachai D, Densmore M, Correa D, Baron R, Lanske B (2011): “Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen Metaphyseal Chondrodysplasia”, FASEB Journal, 25 (9): 3057-67.
19. Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, Toben D, Duda G, Atfi A, Geoffroy V, Horne W, Baron R (2010): “Zfp521 controls bone mass by attenuating Runx2 activity in an HDAC3-dependent manner”, Journal of Cell Biology, 191 (7): 1271-1283.
20. Correa D., Hesse E., Seriwatanachai D, Kiviranta R., Saito H, Yamana K, Neff L., Atfi A., Coillard L., Sitara D., Maeda Y., Warming S., Jenkins NA., Copeland NG., Horne WC., Lanske B., Baron R (2010): “The Transcriptional Co-regulator Zfp521 Is a Parathyroid Hormone-Related Peptide (PTHrP) Target Gene that Transduces Key PTHrP Effects on the Growth Plate”, Developmental Cell Oct 19; 19 (4) 533-46.
21. Hesse E, Kluge G, Atfi A, Correa D, Haasper C, Berding G, Shin H, Viering J, Langer F, Vogt P, Krettek C, Jagodzinski M (2010): “Repair of a segmental long bone defect in Human by implantation of a novel multiple disc graft”, Bone 46 (5):1457-1463.
22. Hesse E, Kiviranta R, Wu M, Correa D, Saito H, Yamana K, Atfi A, Baron R (2010): “Zinc finger protein 521, a new player in bone formation”, Ann NY Acad Sci 1192 (1): 32-37.
23. Wu M, Hesse E, Morvan F, Zhang JP, Correa D, Rowe G, Kiviranta R, Neff L, Philbrick W, Horne WC, Baron R (2009): “Zfp521, a 30 zinc-finger protein, antagonizes Runx2 and promotes bone formation in vivo”, Bone 44 : 528-536.
24. Correa D, Cullinane D, Briceño JC (2003): “Influence of pre-conditioning loads on bovine articular cartilage stress relaxation behavior in confined compression”, Journal of Musculoskeletal Research; 7 (2): 145-150.
25. Correa D, Arroyo J, Llinás A, et al (2002): “Protocolos para el diseño in Vitro de Cartílago Articular animal, basados en métodos de Ingeniería de tejidos” (M.S. Thesis), Revista Colombiana de Biotecnología; 4 (1): 107-113. In review:
1. Somoza RA, Correa D, Labat I, Sternberg H, West MD, Tesar P, Caplan AI: “Mesenchymal stem cells do not make articular cartilage: a transcriptional profile overview” (Tissue Engineering Part A).
1. Correa D, Narcisi R (2016); MSC as chondrocytes, in Tissue Engineering and Regeneration; Springer Editors. Book chapters:
PROFESSIONAL AND HONORARY ORGANIZATIONS:
Grant peer reviewer (National and International):
1. Editorial Board: CellR4 Journal; 2013 – present.
2. Invited Peer Reviewer.
- Area: Stem cell-based therapy and Adult Stem Cell Biology.
Circulation Research; Experimental Cell Research; Stem Cell Research; PLoS; Cell & Tissue Research.
- Area: Growth plate and bone development and physiology.
Molecular and Cellular Biology; Bone. CONFERENCES & MEETINGS: Conference organization/proceedings and panel member:
- Co-organizer: CELLS Musculoskeletal 2016, Amsterdam, Netherlands, October 7-9, 2016.
- Invited Panelist: Advances in the generation of a Chilean Regulatory Framework for Cell Therapy, Viña del Mar, Chile, July 23, 2016. Representing the scientific community in the discussion with the Chilean health authorities regarding the establishment of a regulatory framework for cell-based therapy.
- Panelist/session moderator on OA treatment, OARSI World Congress on Osteoarthritis, Amsterdam, Netherlands, March 31-April 3, 2016.
- Co-organizer (scientific program design and abstract review) of the Latin-American stem cell society (SOLCEMA) annual meeting: Punta Cana, Dominican Republic, October 16-18, 2014; San Salvador, El Salvador, October 30-31, 2015; Viña del Mar, Chile, July 20-23, 2016. Presentations in meetings: